Misoprostol is a synthetic (man-made) prostaglandin that is used to reduce the risk of stomach ulcers in patients treated with nonsteroidal antiinflammatory drugs (NSAIDs, for example, aspirin, ibuprofen, etc.) that are used for pain and various inflammatory conditions, for example, arthritis. Misoprostol is a synthetic prostaglandin analogue that has antisecretory and protective properties, promoting healing of gastric and duodenal ulcers. In these trials there were no significant differences between Misoprostol Tablets and placebo in relief of day or night abdominal pain. No effect of Misoprostol Tablets in reducing the risk of duodenal ulcers was demonstrated, but relatively few duodenal lesions were seen. Find patient medical information for Misoprostol Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Plenty of generic misoprostol preparations are available and are labelled for use for reproductive health indications. However Cytotec, the original misoprostol brand, was only approved for the prevention and treatment of gastric ulcers. If you are taking misoprostol to prevent gastric ulcers, do not take it if you are pregnant. Most of the time, misoprostol is not for use in women who are able to get pregnant. However, there may be times when it is used in these women. Misoprostol, sold under the brandname Cytotec among others, is a medication used to prevent and treat stomach ulcers, start labor, cause an abortion, and treat postpartum bleeding due to poor contraction of the uterus. Misoprostol is a prescription drug used to reducing the risk of NSAID (nonsteroidal anti-inflammatory drugs, including aspirin)–induced gastric ulcers in patients at high risk of complications from gastric ulcer, such as the elderly and patients with concomitant debilitating disease, as well as patients at high risk of developing gastric. PROSTAGLANDINS MISOPROSTOL IN PEPTIC ULCER DISEASE G Watkinson MD FRCP' and F A Akbar MB FRCPz Departments of Medicine and Gastroenterology, Western Infirmary, Glasgow, Scotland', and Medical Department G D Searle & Co Ltd, High Wycombe, England2.